Analysis of the centralized preparation of medicines for systemic treatment of malignant diseases in nine European countries

Introduction: Back in the 1980s many analyses indicated that centralized preparation of cytotoxics gave opportunity to shorten time for their preparation, decrease staff exposure toxic impact, minimize unavoidable residues (to be destroyed) after preparation; therefore, this strategy has been getting implemented different European countries. Purpose : The aim article is make a comparison between requirements and activities on central drugs systemic treatment malignant disease couple chosen countries Bulgaria. Methodology research carried out via online communication with hospital pharmacists directly involved period making detailed interviews target respondents was June–August 2022. Results In 9 participated research, patients diseases are treated only hospitals where solution performed predominantly at pharmacies. Rarely though, one can still encounter practice those departments as process practiced mainly have started recent years (Bulgaria, Croatia, Romania, Lithuania). Typically Ireland Sweden, places hospital, too, (e.g., medical institutions outpatient services or patient’s home). achieved both pharmacies by independent contractors upon hospital’s order; whereas it done so-called solutions prepared. Netherlands, pharmacy technicians dissolve cytotoxics; refers Lithuania, all pharmacy. Mostly deal activity Portugal Estonia, while other Masters technicians/assistant pharmacists; Sweden there Pharmacy Bachelors Pharmacy. Predominantly, safety cabinets isolators used usually choice depends hospital. Standards related national level, they advisable nature Bulgaria, based QUAPOS. mandatory standards.